G(M3) Ganglioside

G(M3) Ganglioside is a lipid of Sphingolipids (SP) class. G(m3) ganglioside is associated with abnormalities such as Metabolic Diseases, Nodular glomerulosclerosis, Renal glomerular disease, Diabetes Mellitus and Hyperglycemia. The involved functions are known as Drug Interactions, Signal Transduction, Down-Regulation, Detergents and Ligand Binding. G(m3) ganglioside often locates in Tissue membrane, Body tissue, Cell surface, Membrane and Extracellular Matrix. The associated genes with G(M3) Ganglioside are PTPN11 gene, anti-IgM, Homologous Gene, SCAP2 gene and N-dodecyl-L-lysine amide. The related lipids are de-N-acetylneuraminyllactosylceramide, Membrane Lipids, Sphingolipids, stearic acid and sialogangliosides.

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Introduction

To understand associated biological information of G(M3) Ganglioside, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with G(M3) Ganglioside?

G(M3) Ganglioside is suspected in Renal glomerular disease, Sandhoff Disease, Nodular glomerulosclerosis, Diabetic Nephropathy, Diabetes, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with G(M3) Ganglioside

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with G(M3) Ganglioside?

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What functions are associated with G(M3) Ganglioside?


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What lipids are associated with G(M3) Ganglioside?

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What genes are associated with G(M3) Ganglioside?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with G(M3) Ganglioside?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with G(M3) Ganglioside

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Authors Title Published Journal PubMed Link
Hedger G et al. Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor. 2016 J Phys Chem B pmid:27109430
Kawashima N et al. Induction of Glycosphingolipid GM3 Expression by Valproic Acid Suppresses Cancer Cell Growth. 2016 J. Biol. Chem. pmid:27539856
Palomo AG et al. Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it's potential therapeutic implications. 2016 Clin. Exp. Metastasis pmid:27449755
Fedoryszak-Kuśka N et al. Glucosylceramide synthase inhibitors D-PDMP and D-EtDO-P4 decrease the GM3 ganglioside level, differ in their effects on insulin receptor autophosphorylation but increase Akt1 kinase phosphorylation in human hepatoma HepG2 cells. 2016 Acta Biochim. Pol. pmid:27172362
Yoshinaga A et al. NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation. 2016 Eur. J. Pharmacol. pmid:27105818
Winner LK et al. A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome. 2016 Hum. Gene Ther. pmid:26975339
Gentilini MV et al. The tumor antigen N-glycolyl-GM3 is a human CD1d ligand capable of mediating B cell and natural killer T cell interaction. 2016 Cancer Immunol. Immunother. pmid:26969612
Gabri MR et al. Racotumomab for treating lung cancer and pediatric refractory malignancies. 2016 Expert Opin Biol Ther pmid:26903265
Wang H et al. Early growth and development impairments in patients with ganglioside GM3 synthase deficiency. 2016 Clin. Genet. pmid:26649472
Xu F et al. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. 2016 ACS Nano pmid:26720275