MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
Phylloquinone is a lipid of Prenol Lipids (PR) class. Phylloquinone is associated with abnormalities such as Vitamin K Deficiency, Malnutrition, Consumption-archaic term for TB, Osteoporosis and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Ingestion, Blood Circulation, Genetic Polymorphism, Intestinal Absorption and Process. Phylloquinone often locates in Blood, Body tissue, Hepatic, Membrane and Entire bony skeleton. The associated genes with phylloquinone are Vitamin K Epoxide Reductase Complex, Subunit 1, GGCX gene, CYP4F2 gene, Alleles and APOE gene. The related lipids are Micelles, 208-G, Fatty Acids, Total cholesterol and Sphingolipids. The related experimental models are Knock-out.
To understand associated biological information of phylloquinone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
phylloquinone is suspected in Vitamin K Deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes, vitamin depletion, Malnutrition, Osteoporosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with phylloquinone
MeSH term | MeSH ID | Detail |
---|---|---|
Thromboembolism | D013923 | 6 associated lipids |
Vitamin K Deficiency | D014813 | 5 associated lipids |
Exanthema | D005076 | 11 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.' (Widhalm JR et al., 2009) and Knock-out are used in the study 'Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.' (Lohmann A et al., 2006).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kopec RE et al. | Comparison of high-performance liquid chromatography/tandem mass spectrometry and high-performance liquid chromatography/photo-diode array detection for the quantitation of carotenoids, retinyl esters, α-tocopherol and phylloquinone in chylomicron-rich fractions of human plasma. | 2013 | Rapid Commun. Mass Spectrom. | pmid:23681818 |
Martinis J et al. | A chloroplast ABC1-like kinase regulates vitamin E metabolism in Arabidopsis. | 2013 | Plant Physiol. | pmid:23632854 |
Crăciun AM and Vermeer C | Apolipoprotein E genotype may influence urinary gammacarboxyglutamate (Gla) concentrations in young individuals. | 2013 | Gen. Physiol. Biophys. | pmid:23817635 |
Plank RM et al. | Vitamin K deficiency bleeding and early infant male circumcision in Africa. | 2013 | Obstet Gynecol | pmid:23884276 |
Reumann S | Biosynthesis of vitamin K1 (phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways. | 2013 | Subcell. Biochem. | pmid:23821151 |
Lovern D and Marbois B | Does menaquinone participate in brain astrocyte electron transport? | 2013 | Med. Hypotheses | pmid:23910074 |
Krüger T et al. | Warfarin induces cardiovascular damage in mice. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23990204 |
Meineke I et al. | Routine micromethod for the determination of vitamin K1 in human plasma. | 2013 | Ther Drug Monit | pmid:24089072 |
Hanzawa F et al. | Dietary sesame seed and its lignan, sesamin, increase tocopherol and phylloquinone concentrations in male rats. | 2013 | J. Nutr. | pmid:23700348 |
Wehler TC et al. | Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective. | 2013 | J. Cancer Res. Clin. Oncol. | pmid:23918349 |