26-Hydroxycholesterol

26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 26-Hydroxycholesterol?

26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Alcoholism D000437 27 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 7

PubChem Associated disorders and diseases

What pathways are associated with 26-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 26-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 26-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 26-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 26-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 26-Hydroxycholesterol?

Transgenic Model

Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).

Knock-out

Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 26-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Kikuchi T et al. Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. 2012 Chest pmid:22281802
Rossouw JE et al. Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. 2012 Circulation pmid:22932256
Kimura A et al. Neonatal cholestasis with increased 3β-monohydroxy-Δ⁵ bile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. 2012 Clin. Chim. Acta pmid:22652365
Fakheri RJ and Javitt NB 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. 2012 Steroids pmid:22366074
Zhang X et al. Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice. 2012 J. Steroid Biochem. Mol. Biol. pmid:22732306
Popp J et al. Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. 2012 J. Neurochem. pmid:22845771
Mateos L et al. side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. 2012 Neurodegener Dis pmid:22236548
Matysik S et al. Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. 2012 Clin. Chem. pmid:22997279
Milagre I et al. Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells. 2012 Neurochem. Int. pmid:22185844
Brauner R et al. Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor α activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. 2012 J. Nutr. pmid:22535758