26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tansley G et al. | Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. | 2012 | Curr Gerontol Geriatr Res | pmid:22649448 |
| Zheng W et al. | Spatial distribution of the pathways of cholesterol homeostasis in human retina. | 2012 | PLoS ONE | pmid:22629470 |
| Rosales-Corral S et al. | Accumulation of exogenous amyloid-beta peptide in hippocampal mitochondria causes their dysfunction: a protective role for melatonin. | 2012 | Oxid Med Cell Longev | pmid:22666521 |
| Cohen E et al. | Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. | 2012 | J Lipids | pmid:22690338 |
| Siam A et al. | Comparative modeling of 25-hydroxycholesterol-7α-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations. | 2012 | J Mol Model | pmid:21541746 |
| Ferreiro E et al. | Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. | 2012 | Int J Cell Biol | pmid:22701485 |
| Bertolotti M et al. | Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21546230 |
| Wolf A et al. | ABC Transporters and the Alzheimer's Disease Enigma. | 2012 | Front Psychiatry | pmid:22675311 |
| Poirier J et al. | High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations. | 2012 | Br. J. Nutr. | pmid:22152646 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |