Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

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Introduction

To understand associated biological information of Cholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cholic acid?

Cholic acid is suspected in Cholestasis, Obesity, Intrahepatic Cholestasis, Diabetes, cholesterol gallstones, Liver diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cholic acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Insulin Resistance D007333 99 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Cholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cholic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cholic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cholic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cholic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cholic acid

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Authors Title Published Journal PubMed Link
Wang Z et al. Caveolae Depletion Contributes to Vasorelaxant Effects of Chenodeoxycholic Acid. 2017 Cell. Physiol. Biochem. pmid:28662517
Giricz Z et al. Hypercholesterolemia downregulates autophagy in the rat heart. 2017 Lipids Health Dis pmid:28330474
Li Y and Zhu C Mechanism of hepatic targeting via oral administration of DSPE-PEG-cholic acid-modified nanoliposomes. 2017 Int J Nanomedicine pmid:28280334
Valanejad L et al. Differential Feedback Regulation of Δ4-3-Oxosteroid 5β-Reductase Expression by Bile Acids. 2017 PLoS ONE pmid:28125709
Yu Y et al. Simple Strategy for Taming Membrane-Disrupting Antibiotics. 2016 Bioconjug. Chem. pmid:27801580
Smits MM et al. Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients. 2016 Diabetes Obes Metab pmid:27451030
Sun L et al. Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. 2016 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:27151938
Li C et al. Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish. 2016 PLoS ONE pmid:26967897
Djanic M et al. Docking-based preliminary study on the interactions of bile acids with drugs at the transporter level in intestinal bacteria. 2016 Eur Rev Med Pharmacol Sci pmid:26914133
Santos-López JA et al. Effects of Silicon vs. Hydroxytyrosol-Enriched Restructured Pork on Liver Oxidation Status of Aged Rats Fed High-Saturated/High-Cholesterol Diets. 2016 PLoS ONE pmid:26807847