Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

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Introduction

To understand associated biological information of Cholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cholic acid?

Cholic acid is suspected in Cholestasis, Obesity, Intrahepatic Cholestasis, Diabetes, cholesterol gallstones, Liver diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cholic acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Insulin Resistance D007333 99 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Cholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cholic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cholic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cholic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cholic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cholic acid

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Authors Title Published Journal PubMed Link
Zhao C et al. An in vitro metabolic system of gut flora and the metabolism of ginsenoside Rg3 and cholic acid. 2014 Eur J Drug Metab Pharmacokinet pmid:23749587
Manley S et al. Suppression of autophagic flux by bile acids in hepatocytes. 2014 Toxicol. Sci. pmid:24189133
Shiraishi T and Nielsen PE Cellular delivery of peptide nucleic acids (PNAs). 2014 Methods Mol. Biol. pmid:24297361
Öner Ö et al. Mechanisms of cholesterol-lowering effects of lactobacilli and bifidobacteria strains as potential probiotics with their bsh gene analysis. 2014 J. Mol. Microbiol. Biotechnol. pmid:24158048
Vařeková RS et al. MotiveValidator: interactive web-based validation of ligand and residue structure in biomolecular complexes. 2014 Nucleic Acids Res. pmid:24848013
Shao Y et al. Block and random copolymers bearing cholic acid and oligo(ethylene glycol) pendant groups: aggregation, thermosensitivity, and drug loading. 2014 Biomacromolecules pmid:24725005
Baptissart M et al. Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice. 2014 Hepatology pmid:24798773
Penno CA et al. 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. 2014 Mol Metab pmid:25061560
Liu J et al. Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. 2014 Toxicol. Sci. pmid:25055961
Cheng X et al. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum. 2014 J. Pharmacol. Exp. Ther. pmid:25034404