Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

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Introduction

To understand associated biological information of Cholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cholic acid?

Cholic acid is suspected in Cholestasis, Obesity, Intrahepatic Cholestasis, Diabetes, cholesterol gallstones, Liver diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cholic acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Insulin Resistance D007333 99 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Cholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cholic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cholic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cholic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cholic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cholic acid

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Authors Title Published Journal PubMed Link
Kołodziejczyk MK et al. Surface activity of novel surface active compounds, products of catalytic oxyethylation of cholic acid and their micellar adducts with selected lipophilic therapeutic agents. 2014 Jan-Feb Acta Pol Pharm pmid:24779200
Zhao C et al. An in vitro metabolic system of gut flora and the metabolism of ginsenoside Rg3 and cholic acid. 2014 Eur J Drug Metab Pharmacokinet pmid:23749587
Öner Ö et al. Mechanisms of cholesterol-lowering effects of lactobacilli and bifidobacteria strains as potential probiotics with their bsh gene analysis. 2014 J. Mol. Microbiol. Biotechnol. pmid:24158048
Kazgan N et al. Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis. 2014 Gastroenterology pmid:24389307
Jia X et al. A possible role of chenodeoxycholic acid and glycine-conjugated bile acids in fibrotic steatohepatitis in a dietary rat model. 2014 Dig. Dis. Sci. pmid:24448653
Shang J et al. UHPLC/Q-TOF MS-based plasma metabolic profiling analysis of the bleeding mechanism in a rat model of yeast and ethanol-induced blood heat and hemorrhage syndrome. 2014 J Pharm Biomed Anal pmid:24469093
Hrycay E et al. Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice. 2014 Mol. Cell. Biochem. pmid:24399466
Vařeková RS et al. MotiveValidator: interactive web-based validation of ligand and residue structure in biomolecular complexes. 2014 Nucleic Acids Res. pmid:24848013
Sun X et al. Metabonomics evaluation of urine from rats administered with phorate under long-term and low-level exposure by ultra-performance liquid chromatography-mass spectrometry. 2014 J Appl Toxicol pmid:23280859
Myronovych A et al. Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. 2014 Obesity (Silver Spring) pmid:23804416