Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

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Introduction

To understand associated biological information of Cholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cholic acid?

Cholic acid is suspected in Cholestasis, Obesity, Intrahepatic Cholestasis, Diabetes, cholesterol gallstones, Liver diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cholic acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Insulin Resistance D007333 99 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Cholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cholic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cholic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cholic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cholic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cholic acid

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Authors Title Published Journal PubMed Link
Tsuchiya H et al. Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. 2015 Gastroenterology pmid:25701738
Bodewes FA et al. Cholic acid induces a Cftr dependent biliary secretion and liver growth response in mice. 2015 PLoS ONE pmid:25680200
Jiang W et al. Multiscale approach to investigate self-assembly of telodendrimer based nanocarriers for anticancer drug delivery. 2015 Langmuir pmid:25532019
Shih DM et al. PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. 2015 FASEB J. pmid:25477283
Gu S et al. A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine. 2015 Mol Biosyst pmid:25411028
Kaur A et al. Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1. 2015 Diabetes pmid:25338812
Desai MS et al. Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis. 2015 Liver Int. pmid:24330504
Janout V et al. Taming Amphotericin B. 2015 Bioconjug. Chem. pmid:26340430
Amjad MW et al. In Vivo Antitumor Activity of Folate-Conjugated Cholic Acid-Polyethylenimine Micelles for the Codelivery of Doxorubicin and siRNA to Colorectal Adenocarcinomas. 2015 Mol. Pharm. pmid:26567518
Nachajski MJ et al. Usefulness of Rosen's postulate for studying the relationship between the structure of cholic acid oxyethylation products and the process of solubilization of lipophilic therapeutic agents (BCS class II and IV) in aqueous solutions in equilibrium. 2014 Jul-Aug Acta Pol Pharm pmid:25272890