Tetrahydrodeoxycorticosterone

Tetrahydrodeoxycorticosterone is a lipid of Sterol Lipids (ST) class. Tetrahydrodeoxycorticosterone is associated with abnormalities such as Cerebrovascular accident, Epilepsy, Status Epilepticus, Still and Liver diseases. The involved functions are known as Chromosome Pairing, Adjudication, inhibitors, Neuronal Transmission and Synthesis. Tetrahydrodeoxycorticosterone often locates in Entire oral cavity, Body tissue, Pole, Brain region and Cell surface. The associated genes with Tetrahydrodeoxycorticosterone are ADRBK1 gene. The related lipids are pregnane-20-one, allotetrahydrodeoxycorticosterone, Steroids, 17-phenylandrost-16-en-3-ol and pregnenolone sulfate. The related experimental models are Transgenic Model.

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Introduction

To understand associated biological information of Tetrahydrodeoxycorticosterone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tetrahydrodeoxycorticosterone?

Tetrahydrodeoxycorticosterone is suspected in Cerebrovascular accident, Epilepsy, Hepatic Encephalopathy, Status Epilepticus, Liver diseases, Convulsions and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tetrahydrodeoxycorticosterone

MeSH term MeSH ID Detail
Epilepsy, Absence D004832 5 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Tetrahydrodeoxycorticosterone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tetrahydrodeoxycorticosterone?

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What functions are associated with Tetrahydrodeoxycorticosterone?


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What lipids are associated with Tetrahydrodeoxycorticosterone?

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What genes are associated with Tetrahydrodeoxycorticosterone?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tetrahydrodeoxycorticosterone?

Transgenic Model

Transgenic Model are used in the study 'GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo.' (Johansson M et al., 2016).

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NCBI Entrez Crosslinks

All references with Tetrahydrodeoxycorticosterone

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Authors Title Published Journal PubMed Link
Wongsamitkul N et al. Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors. 2016 J. Biol. Chem. pmid:27382064
Wilkins ME et al. Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation. 2016 J. Physiol. (Lond.) pmid:27028707
Johansson M et al. GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo. 2016 J. Steroid Biochem. Mol. Biol. pmid:26523675
Johansson M et al. GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26138462
Villumsen IS et al. Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. 2015 BMC Neurosci pmid:25887256
Shiri Z et al. Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats. 2015 Neurobiol. Dis. pmid:25814046
Herrington R et al. Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal CA3 area. 2015 Eur. J. Neurosci. pmid:25471484
Adams JM et al. Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. 2015 Neuropharmacology pmid:25278033
Marowsky A and Vogt KE Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. 2014 Front Neural Circuits pmid:24723854
Kerti-Szigeti K et al. Synaptic GABAA receptor clustering without the γ2 subunit. 2014 J. Neurosci. pmid:25080584