Tetrahydrodeoxycorticosterone

Tetrahydrodeoxycorticosterone is a lipid of Sterol Lipids (ST) class. Tetrahydrodeoxycorticosterone is associated with abnormalities such as Cerebrovascular accident, Epilepsy, Status Epilepticus, Still and Liver diseases. The involved functions are known as Chromosome Pairing, Adjudication, inhibitors, Neuronal Transmission and Synthesis. Tetrahydrodeoxycorticosterone often locates in Entire oral cavity, Body tissue, Pole, Brain region and Cell surface. The associated genes with Tetrahydrodeoxycorticosterone are ADRBK1 gene. The related lipids are pregnane-20-one, allotetrahydrodeoxycorticosterone, Steroids, 17-phenylandrost-16-en-3-ol and pregnenolone sulfate. The related experimental models are Transgenic Model.

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Introduction

To understand associated biological information of Tetrahydrodeoxycorticosterone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tetrahydrodeoxycorticosterone?

Tetrahydrodeoxycorticosterone is suspected in Cerebrovascular accident, Epilepsy, Hepatic Encephalopathy, Status Epilepticus, Liver diseases, Convulsions and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tetrahydrodeoxycorticosterone

MeSH term MeSH ID Detail
Epilepsy, Absence D004832 5 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Tetrahydrodeoxycorticosterone

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tetrahydrodeoxycorticosterone?

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What functions are associated with Tetrahydrodeoxycorticosterone?


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What lipids are associated with Tetrahydrodeoxycorticosterone?

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What genes are associated with Tetrahydrodeoxycorticosterone?

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What common seen animal models are associated with Tetrahydrodeoxycorticosterone?

Transgenic Model

Transgenic Model are used in the study 'GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo.' (Johansson M et al., 2016).

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NCBI Entrez Crosslinks

All references with Tetrahydrodeoxycorticosterone

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Authors Title Published Journal PubMed Link
Wang L et al. Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control. 2008 J. Neurosci. pmid:19020037
Ahboucha S et al. Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis. 2008 Neurogastroenterol. Motil. pmid:18482252
Vardya I et al. Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex. 2008 J. Neurophysiol. pmid:18463187
Han SM and Youn DH GABAA receptor-mediated tonic currents in substantia gelatinosa neurons of rat spinal trigeminal nucleus pars caudalis. 2008 Neurosci. Lett. pmid:18585436
Frye CA et al. Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area. 2008 Behav. Brain Res. pmid:18590775
Pisu MG et al. Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy. 2008 J. Neurochem. pmid:18624910
Zheleznova N et al. alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids. 2008 Br. J. Pharmacol. pmid:18204487
Tuveri A et al. Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy. 2008 Epilepsia pmid:18325018
Frye CA et al. Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats. 2008 Pharmacol. Biochem. Behav. pmid:18786558
Frye CA and Walf AA In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C. 2008 Brain Res. pmid:18671954